Hostazym X (endo-1,4-beta-xylanase) as a feed additive for poultry, piglets and pigs for fattening

Hostazym X is an enzyme preparation of xylanase produced by a non-genetically modified strain of Trichoderma citrinoviride. The fermentation product showed negative results in a bacterial reverse mutation assay. The results of an in vitro chromosomal aberration test and of an in vivo comet assay indicate the presence of genotoxic activity in the product.
Although the tolerance studies provided in target species did not indicate any adverse effect of the additive, the FEEDAP Panel, taking into account the genotoxic hazard from the product, cannot conclude on the safety of the additive for the target species.